認(rèn)知儲備調(diào)節(jié)輕度創(chuàng)傷性腦損傷后的認(rèn)知結(jié)果
Abstract
Objective: To investigate whether cognitive reserve moderates differences in ognitive functioning between patients with mild traumatic brain injury (MTBI) and controls without MTBI and to examine whether patients with postconcussion syndrome have lower cognitive functioning than patients without postconcussion syndrome at 2 weeks and 3 months after injury.
摘要
目的: 研究認(rèn)知儲備是否能調(diào)節(jié)輕度創(chuàng)傷性腦損傷(MTBI)患者和無MTBI對照組之間的認(rèn)知功能差異,，并檢查腦震蕩后綜合征患者在傷后2周和3個月的認(rèn)知功能是否低于無腦震蕩后綜合征患者,。
Design: Trondheim MTBI follow-up study is a longitudinal controlled cohort study with cognitive assessments 2 weeks and 3 months after injury.
設(shè)計: 特隆赫姆MTBI隨訪研究是一項(xiàng)縱向?qū)φ贞?duì)列研究,，在損傷后2周和3個月進(jìn)行認(rèn)知評估。
Setting: Recruitment at a level 1 trauma center and at a general practitioner-run, outpatient clinic.
背景: 向1級創(chuàng)傷中心和一個全科醫(yī)生運(yùn)行的門診診所招募,。
Participants: Patients with MTBI (nZ160) according to the World Health Organization criteria, trauma controls (nZ71), and community controls (nZ79) (NZ310).
參與者: 根據(jù)世界衛(wèi)生組織標(biāo)準(zhǔn)的創(chuàng)傷控制(nZ71)和社區(qū)控制(nZ79) (NZ310)的MTBI患者(nZ160)。
Main Outcome Measures: A cognitive composite score was used as outcome measure. The Vocabulary subtest was used as a proxy of cognitive reserve. Postconcussion syndrome diagnosis was assessed at 3 months with the British Columbia Postconcussion Symptom Inventory.
主要結(jié)果指標(biāo): 以認(rèn)知復(fù)合得分作為結(jié)果指標(biāo),。用詞匯子測試評估認(rèn)知儲備,。腦震蕩后綜合征3個月時，通過不列顛哥倫比亞省腦震蕩后癥狀量表進(jìn)行評估進(jìn)行診斷,。
Results: Linear mixed models demonstrated that the effect of vocabulary scores on the cognitive composite scores was larger in patients with MTBI than in community controls at 2 weeks and at 3 months after injury (PZ.001). Thus, group differences in the cognitive composite score varied as a function of vocabulary scores, with the biggest differences seen among participants with lower vocabulary scores. There were no signifificant differencesin the cognitive composite score between patients with (nZ29) and without (nZ131) postconcussion syndrome at 2 weeks or 3 months after injury.
結(jié)果: 線性混合模型顯示,，在損傷后2周和3個月的輕度創(chuàng)傷性腦損傷MTBI患者認(rèn)知復(fù)合得分的影響大于社區(qū)對照組(PZ.001)。因此,，根據(jù)詞匯得分,， 認(rèn)知復(fù)合得分的組間差異有所改變，詞匯得分較低者的組間差異最大,。在受傷后2周或3個月,，有(nZ29)和沒有(nZ131)腦震蕩后綜合征的患者之間的認(rèn)知復(fù)合評分沒有顯著差異。
Conclusion: Cognitive reserve, but not postconcussion syndrome, was associated with cognitive outcome after MTBI. This supports the cognitive reserve Hypothesis in the MTBI context and suggests that persons with low cognitive reserve are more vulnerable to reduced cognitive functioning if they sustain an MTBI.
結(jié)論: 非腦震蕩后綜合征認(rèn)知儲備與MTBI后的認(rèn)知結(jié)果相關(guān),。這驗(yàn)證了MTBI背景下認(rèn)知儲備的假說,，并聲稱認(rèn)知儲備低者，如果仍保持MTBI狀態(tài),，更容易降低認(rèn)知功能,。
