自發(fā)性冠狀動(dòng)脈夾層及其與纖維肌發(fā)育異常和其他血管異常的關(guān)系
OBJECTIVE
Fibromuscular dysplasia (FMD) has recently been associated with spontaneous coronary artery dissection (SCAD).
最近研究表明,，纖維肌發(fā)育不良（FMD）與自發(fā)性冠狀動(dòng)脈夾層（SCAD）相關(guān),。我們?cè)噲D進(jìn)一步闡明兩者間的關(guān)系,。
METHODS
We sought to further elucidate the association of FMD with SCAD. We performed a retrospective cohort review of patients with SCAD evaluated at our institution from 2008 to 2019. Baseline characteristics, coronary angiographic data, and screening for FMD were recorded. In patients who completed screening for FMD, variables were compared between patients with FMD and those without. We identified 51 patients with SCAD, all of whom were female, with a mean age of 46.8 years.
2008年至2019年對(duì)在我們機(jī)構(gòu)進(jìn)行評(píng)估的SCAD患者進(jìn)行了回顧性隊(duì)列研究,。記錄了基線特征、冠狀動(dòng)脈造影數(shù)據(jù)和FMD篩查,。完成FMD篩查的患者中,，比較有FMD的患者和沒(méi)有FMD的患者之間的變量,。確定51例SCAD患者，全部為女性,，平均年齡為46.8歲,。
RESULTS
A quarter of patients underwent percutaneous coronary intervention (PCI) and half of those suffered a complication during PCI. 78% of patients underwent complete screening for FMD, of which 63% were diagnosed with multifocal FMD. Vascular abnormalities other than FMD were found in 70% of screened patients. Patients with FMD were older than those without FMD (50.7 vs 42.6 years, p?=?0.006). FMD was more frequently associated with type 2 SCAD (84% vs 47%, p?=?0.025), tortuous non-SCAD coronaries (96% vs 53%, p?=?0.002), and other vascular abnormalities (84% vs 47%, p?=?0.03).
四分之一患者接受了經(jīng)皮冠狀動(dòng)脈介入治療（PCI），一半患者在PCI期間發(fā)生了并發(fā)癥,。78％的患者接受了FMD的全面篩查,，其中63％被診斷為多灶性FMD。在接受篩查的患者中,，70％患者發(fā)現(xiàn)FMD以外的血管異常,。FMD患者比沒(méi)有FMD的患者年齡更大（50.7 vs 42.6歲，p = 0.006）,。 FMD與2型SCAD（84％vs 47％,，p = 0.025）、非SCAD冠狀動(dòng)脈病變（96％vs 53％,，p = 0.002）和其他血管異常（84％vs 47％,，p = 0.03）關(guān)聯(lián)性較高。
CONCLUSIONS
In conclusion, the majority of patients within the all-female cohort with SCAD were found to have FMD. Other vascular abnormalities were also common. Patients with FMD were older and were more likely to have type 2 SCAD, tortuous non-SCAD coronary arteries, and other vascular abnormalities.
總之,，在所有患有SCAD的女性隊(duì)列中,，大多數(shù)患者被發(fā)現(xiàn)纖維肌發(fā)育不良。其他血管異常也很常見(jiàn),?；加?/span>FMD的患者年齡較大，更可能患有2型SCAD,、非SCAD冠狀動(dòng)脈和其他血管異常,。
