Abstract
Background: To examine whether periodontitis is associated with the presence and severity of radiographic knee osteoarthritis (OA).
Methods: Using data from the Korea National Health and Nutrition Examination Survey between 2010 and 2013, participants over the age of 50 were included in this study. Dental examinations and knee radiographs are performed in participants aged ≥50 years in this cohort. Periodontitis was defined using the community periodontal index, which was determined by measuring periodontal probing depth. The definition of adiographic knee OA was based on the Kellgren-Lawrence (K-L) grading system, which determined a K-L class ≥2 to be radiographic knee OA. The associations between periodontitis and presence and severity of radiographic knee OA were examined using logistic regression analyses.
Results: Among 7969 total participants, 965 men and 2078 women had radiographic knee OA. Periodontitis was observed in 1,185 (39.4%) people among those who had radiographic knee OA. Periodontitis (adjusted odds radio [aOR] 1.21, 95% confidence interval 1.05 to 1.40) was associated with radiographic knee OA after adjusting for variables including age, sex, body mass index, socioeconomic status, diabetes, and dental status. Participants were more likely to have radiographic knee OA as the severity of periodontitis increased (non-severe periodontitis, aOR 1.14 [0.98 to 1.32]; severe periodontitis, aOR 1.47 [1.17 to 1.85]). Moreover, the presence of periodontitis significantly increased with an increasing K-L class (class 1, aOR 1.30 [1.09 to .54]; class 2, aOR 1.32 [1.08 to 1.60]; class 3, aOR 1.39 [1.14 to 1.70]; class 4, aOR 1.45 [1.11 to 1.90]).
Conclusion: Periodontitis is associated with the presence and severity of radiographic knee OA.
背景：研究牙周炎是否與膝骨性關節(jié)炎(OA)的存在及嚴重程度有關,。
方法：使用2010年至2013年韓國國家健康和營養(yǎng)檢查調查的數(shù)據(jù),，50歲以上的參與者被納入本研究中。在這個隊列中,，年齡≥50歲的參與者進行了牙科和膝關節(jié)x線片檢查,。牙周炎采用社區(qū)牙周指數(shù)進行定義，即通過測量牙周探診深度來確定。膝關節(jié)骨性關節(jié)炎的定義基于Kellgren-Lawrence (K-L)分級系統(tǒng),，該分級系統(tǒng)判定K-L分級≥2為膝關節(jié)骨性關節(jié)炎,。使用邏輯回歸分析檢查牙周炎與膝關節(jié)骨性關節(jié)炎的存在和嚴重程度之間的關系。
結果: 7969名參與者中,，965名男性和2078名女性有膝關節(jié)骨性關節(jié)炎,。1,185例(39.4%)膝關節(jié)骨性關節(jié)炎患者中觀察到患有牙周炎。在調整了年齡,、性別,、體重指數(shù)、社會經(jīng)濟地位,、糖尿病和牙齒狀況等變量后,，牙周炎(校正比值比[aOR] 1.21, 95%置信區(qū)間1.05至1.40)與膝關節(jié)骨性關節(jié)炎相關。隨著牙周炎嚴重程度的增加,，受試者更有可能發(fā)生膝關節(jié)骨性關節(jié)炎(非重度牙周炎,，aOR 1.14 [0.98 ~ 1.32];重試牙周炎，aOR 1.47[1.17 - 1.85]),。此外,，隨著K-L等級的增加，牙周炎的發(fā)病率顯著增加(I級,，aOR 1.30 [1.09 ~ .54]; II級,aOR 1.32[1.08至1.60];III級,aOR 1.39[1.14至1.70];IV級,aOR 1.45[1.11至1.90]),。
結論: 牙周炎與膝關節(jié)骨性關節(jié)炎的存在及嚴重程度有關。
